P194: GPR15-mediated trafficking of antibody-secreting cells in IBD
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.06.2026
End date : 31.05.2027
Project details
Scientific Abstract
This project investigates the effects of GPR15:GPR15L on the gut-homing of antibody-secreting cells in context of inflammatory bowel disease. It studies the differential influence of this trafficking programme on IgA/IgG-producing cells and whether a modulation of this mechanism affects intestinal inflammatory processes and the composition of the gut microbiome. Therefore, in vitro and in vivo assays will be performed combined with transcriptomic and metagenomic data analyses.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
