E42: Elucidating the roles of long-lived RNAs in motor neuron diseases
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.06.2026
End date : 30.11.2028
Project details
Scientific Abstract
The molecular basis of motor neuron vulnerability in motor neuron diseases (MNDs) remains poorly understood. RNA dysregulation has been linked to MNDs, and LL-RNAs have recently been identified as a potentially critical component of neural longevity. We found an enrichment of long-lived RNAs (LL-RNAs) in human motor neurons. Thus, this project will investigate the mechanistic role of LL-RNAs in MNDs using brain organoids, aiming to identify novel biomarkers and therapeutic targets.
