D45: S100A8 and A9 go nuclear: regulation of inflammation and clinical impact for muscle invasive bladder cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.06.2026
End date : 30.11.2028
Project details
Scientific Abstract
We demonstrate inflammation of 218 urothelial bladder cancers is driven by the Endogenous Retrovirus interferon axis and identify five clusters. Cytokines S100A8/A9 were the highest significantly differentially expressed genes. S100A8/A9 also function in the nucleus and transcriptionally co-activate ERVs, but repress interferon stimulated genes. Analyses of bladder tumors for inflammation, S100A8/A9 and ERVs will help to understand tumor progression and maintenance predicting clinical outcome.
