P151-OA: Nephronectin-Integrin: From podocyte nephronectin secretion into the ECM and back to podocyte integrity
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2024
End date : 30.09.2025
Project details
Scientific Abstract
In this project we want to analyze by which mechanisms the extracellular matrix (ECM) protein nephronectin (NPNT) is secreted. Inhibition of e. g. exocytosis and lysosomal trafficking will shed light on NPNT export and deposition in the ECM. In addition, we want to identify interaction partners of NPNT on podocytes within the superfamily of integrins and analyze the quality of these interactions both in vitro and in vivo.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 4 – Nephrology and Hypertension
