IZKF-J78 (M1): Role of GPX4-regulated ferroptosis in innate immunity to microbial infection

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.10.2019

End date : 15.02.2022

Project details

Scientific Abstract

Ferroptosis is a recently identified type of programed necrotic cell death which is tightly regulated by GPX4. In this project the exact role of GPX4 and ferroptosis in myeloid cells under steady state conditions and during Salmonella Typhimurium infection will be investigated. GPX4-regulated ferroptotic cell death might display a new therapeutic target for treatment of acute infections in human patients.

Involved:

Stefan Wirtz Project Member Roland Lang Project Member

Contributing FAU Organisations:

Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Professur für Angeborene Immunität und Pathogenerkennung Medizinische Fakultät

Research Areas

Microscope SVG Junior Projects Field of Research