P130: Understanding the mechanism of nuclear envelope breakdown during NETosis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2023
End date : 30.06.2024
Extension date: 31.12.2024
Project details
Scientific Abstract
During the course of neutrophil extracellular trap (NET) formation, intracellular calcium plays essential role in activation of enzymes like PAD-4 and calpain which are involved in chromatin decondensation. The preliminary data showed the involvement of calpain in degradation of the nuclear envelope protein nesprin. Here we will delineate the exact role of calpain in degradation of nuclear envelope protein nesprin and unfold the mechanism of nuclear membrane breakdown during NET formation.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
