P117: Mechanisms of T cell migration into central nervous system in neurodegeneration
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2023
End date : 31.12.2023
Extension date: 30.04.2025
Project details
Scientific Abstract
T cells migrate to and impact the central nervous system (CNS) during disease. We show that diseased CNS allows stronger T cell migration by yet unknown mechanisms. Here, T cell-attracting mechanisms of neurodegenerative CNS tissue and T cell-driven neurodegenerative pathomechanisms will be investigated in a human stem cell-based 3D CNS model using RNA sequencing and biochemical methods. Data will provide mechanistic insights how T cell migration is facilitated by CNS during neurodegeneration.
Involved:
Contributing FAU Organisations:
Professur für Stammzell-Modelle seltener neuraler Erkrankungen
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
