J076: The role of itaconate-mediated metabolic reprogramming in osteoclasts
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.10.2019
End date : 15.04.2022
Project details
Scientific Abstract
The maintenance of healthy bone relies on a balance between bone formation by osteoblasts and bone resorption by osteoclasts. Recent findings indicate that the differentiation and function of osteoclasts can be regulated by certain changes in the cellular metabolism. Accordingly, we demonstrated that the metabolite itaconate inhibits osteoclastogenesis. The major aim of the presented project is the investigation of molecular mechanisms underlying this function of itaconate.
Involved:
Katerina Kachler
Project Leader
Uwe Sonnewald
Project Member
Jörg Hofmann
Project Member
Arif Bülent Ekici
Project Member
Contributing FAU Organisations:
Lehrstuhl für Biochemie
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Institute of Human Genetics
Medizinische Fakultät
