D030 (Experim. Medizin II): Functional role of axin anchoring to microtubules in Wnt signaling
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2020
End date : 31.08.2022
Extension date: 28.02.2023
Project details
Scientific Abstract
Axin is a key negative regulator of the oncogenic Wnt/beta-catenin pathway scaffolding the beta-catenin destruction complex. We suggest that the newly found anchoring of axin to microtubules (MTs) is of functional importance for regulating the pathway. We will (i) describe the dynamics of axin association with MTs; (ii) determine the biochemical basis of this interaction and its regulation by phosphorylation; and (iii) define the functional role of axin anchoring to MTs in Wnt signaling.
Involved:
Contributing FAU Organisations:
Optical Imaging Center Erlangen (OICE)
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) (EXP2MED)
Medizinische Fakultät
