A087: Role of DC heterogeneity and natural antibodies for the disease outcome in cutaneous Leishmania infection
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.12.2020
End date : 31.05.2023
Extension date: 30.11.2023
Project details
Scientific Abstract
Dendritic Cells (DCs) are indispensable for the protection from pathogens. Additionally, natural antibodies (nAbs) reacting to evolutionary conserved epitopes foster fast targeted response. Leishmaniasis is an important tropical disease with different manifestations. However, the first events in infection and determination of T/NK cell responses by DCs and nAbs are not fully understood. We now aim to unravel early determining factors for clinical outcome in leishmaniasis on a single cell level.
