A077: HIF pathway activation in B cells regulates postmenopausal bone loss
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.12.2020
End date : 15.06.2023
Extension date: 15.12.2023
Project details
Scientific Abstract
While the influence of T cells on bone homeostasis has been well characterized, less is known about the role of B cells. Despite that B cells are able to produce RANKL, the major cytokine regulating osteoclast differentiation, its regulation of expression remains unclear. B cells reside in the low oxygen concentrations bone niche, and adapt to the environment through the expression of HIFs. I therefore hypothesize that HIF expression in B cells could influence the development of osteoporosis.
Involved:
Contributing FAU Organisations:
Professur für Experimentelle Immuntherapie
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
