J097: Targeting immune-metabolic dysfunction of reconstituting NK cells upon stem cell transplantation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 30.06.2024
Project details
Scientific Abstract
The metabolism of reconstituting NK cells upon autologous SCT is altered in lymphoma patients who experience an early relapse upon transplantation. We intend to decipher the underlying cellular and molecular mechanism to identify factors leading to the increased relapse risk and to reveal potential opportunities to modify them. This will lay the foundation for further projects investigating NK cell reconstitution upon allogeneic SCT and CAR-transfected NK cell expansion in tumor patients.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 5 – Haematology and Oncology
Medizinische Fakultät
