E030: Th17 and beyond: immune-mediated neurotoxicity determines onset and progression in Parkinsons disease

FAU own research funding: EFI / IZKF / EAM ...

Start date : 01.04.2020

End date : 30.09.2022

Extension date: 31.03.2023

Overview

Publications

(17)

Project details

Scientific Abstract

Recent data demonstrate profound immunological alterations in Parkinsons disease (PD). We study the contribution of the peripheral immune system to onset and progression in PD. Specifically, we perform a comprehensive characterization of peripheral immunity in early vs. late onset with rapid vs. slow disease progression PD patients. Subsequently, we will determine neurotoxicity in human autologous co-cultures of stem cell-derived midbrain neurons and specific immune cells.

Involved:

Beate Winner Project Leader Jürgen Winkler Project Leader

Contributing FAU Organisations:

Professur für Stammzell-Modelle seltener neuraler Erkrankungen Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Professur für Molekulare Neurologie Medizinische Fakultät

Research Areas