IZKF-J71 (M4): Inhibition of the purinergic receptor P2Y2R as a potential therapeutic intervention in ADPKD
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2019
End date : 30.06.2021
Project details
Scientific Abstract
The aim of our project is to descramble the role of the purinergic receptor P2Y2R in the context of Ca2+-dependent Cl--secretion as a main course of cyst growth in ADPKD. We will use our novel PKD1-deficient 3D cyst model and micropuncture cysts to analyse the effects of luminal ATP as well as the P2 inhibitor Suramin. In addition, we will test for the impact of P2Y2R knockout on the cystic burden in our PKD1 knockout mouse model and determine the therapeutic potential of Suramin in vivo.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 4 – Nephrology and Hypertension
Medizinische Fakultät
