F009: Generation of novel 3D co-culture systems for study of glomerular functions ex vivo

FAU own research funding: EFI / IZKF / EAM ...


Start date : 16.06.2020

End date : 15.12.2022

Extension date: 15.06.2023


Project details

Scientific Abstract

In search for better glomerular ex vivo models, we studied 3D glomerular co-cultures and generated stem cell (iPSC)-derived personalized podocytes from patients with genetic FSGS. These cells were characterized using bulk sequencing, marker expression, actin polymerization, morphology and response to different substances used in the clinic to foresee individual response to treatment. At the moment, CRISPR-Cas9 based rescue experiments of mutated iPSC derived patient podocytes are performed.

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