P058 (Exp. Medizin II): Optimisation and characterisation of a Wnt signalling-inhibiting peptide with potential for cancer therapy
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.04.2020
End date : 15.04.2021
Project details
Scientific Abstract
A synthetic peptide inhibits Wnt/ß-catenin signalling and growth of colorectal cancer cells by augmenting conductin-mediated ß-catenin degradation. Here, we want to improve peptide activity by optimising its functional and its cell permeability-providing parts. Then, cell penetration kinetics, cellular distribution and stability will be characterised, and the optimised peptide will be functionally compared to the old version to verify improvement of our peptide towards therapeutic applicability.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) (EXP2MED)
Medizinische Fakultät
