A092: Targeting draining lymph node scaffold cells to induce immune tolerance
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.09.2020
End date : 28.02.2023
Extension date: 29.02.2024
Project details
Scientific Abstract
As lymphatics in the inflamed joint in rheumatoid Arthritis drain specifically the popliteal lymph node (pLN) where the adaptive immune response is initiated, we investigated a population of stromal cells in the pLN, namely the fibroblastic reticular cells (FRC). Our preliminary data show a significant immunomodulatory potential of pLN FRCs in inflammatory arthritis mouse models. Therefore, we hypothesize that specifically pLN stromal FRCs play a so far neglected role in the early onset of RA.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
