P061: Modified proteins in the gut break the tolerance and initiate autoimmune arthritis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.04.2020
End date : 31.03.2021
Project details
Scientific Abstract
In RA the degree of inflammation and autoantibody positivity are important initiators of bone destruction. Interestingly, among IBD patients with chronic gut inflammations about 45% were positive for at least one arthritis antibody. However, despite the reported higher incidence of bone destruction in IBD patients, it remains elusive whether and how local gut antibody production and their different posttranslational modifications during gut inflammations directly contribute to RA.
Involved:
Contributing FAU Organisations:
Department of Medicine 3 – Rheumatology and Immunology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
