D031 (Biochemie u. Mol. Medizin: Modulation of oncogene-induced senescence by cell-matrix adhesion
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.03.2020
End date : 15.09.2022
Extension date: 15.03.2023
Project details
Scientific Abstract
Oncogene-induced senescence (OIS) was recently introduced as a strong tumor suppressive mechanism seen e.g. in development of nevi out of melanocytes after BRAF mutation. Tumor cells like melanoma obviously can overcome these limiting mechanisms by further changes, however the molecular mechanisms leading to and overcoming OIS are just being started to be understood. We aim to understand the role of cell adhesion processes and mechanotransduction in induction and overcoming OIS.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Biochemie und Molekulare Medizin
Medizinische Fakultät
