P034 (Biochemie, Mol. Medizin): Myeloid-specific functions of the EMT-inducer ZEB1 in colorectal cancer.
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.01.2019
End date : 15.01.2020
Project details
Scientific Abstract
In colorectal cancer (CRC), the transcription factor ZEB1 is upregulated in tumor cells and tumor-associated macrophages. As only its tumor-promoting role in tumor cells is known, we are analyzing myeloid-specific ZEB1 knockout mice. Our preliminary data suggest that ZEB1 plays a role in macrophage polarization, intestinal inflammation and CRC growth. Here, we will explore novel functions of ZEB1 in immune homeostasis, macrophage plasticity, immune-modulation in CRC and colitis-associated CRC.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung
Medizinische Fakultät
