Bavarian Research Association Interaction of Human Brain Cells (ForInter)

Third Party Funds Group - Overall project


Acronym: ForInter

Start date : 01.03.2019

End date : 28.02.2023

Extension date: 31.12.2023

Website: https://www.bayfor.org/en/bavarian-expertise/bavarian-research-associations/associations/association/forinter.html


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Project details

Short description

ForInter aims to analyse the cell-cell interaction of human neural cells. The studies will use from induced plurioptent stem cells (IPSCs) derived neurons, oligodendrocytes, astrocytes, microglia, pericytes.

Scientific Abstract

The human brain has a complicated architecture of divers and specialised cells, like neurons, glial and microglial cells. These cells form and interact in functional and dynamic circuits, thus providing the basis for the complex functions of the human brain.

Even though our understanding of the human brain has made tremendous advances in recent decades, many questions about the physiological and pathological functions of the human brain remain unanswered until to date. The structural analysis of the brain can be performed in post mortem brain tissue, but these neuroanatomical and pathological studies only represent a static approach and reflect the specific variables only at a fixed point of time. For a deeper understanding, dynamic and functional investigations of the interaction between the different cells in the human brain are required.

Therefore, the Bavarian Consortium ForInter aims to investigate the interaction between the different cell types in the human brain using multidimensional cell culture systems.

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