Third party funded individual grant
Acronym: CLATHROPROBES
Start date : 01.01.2018
End date : 31.12.2023
Website: https://clathroprobes.chem.uni.wroc.pl
The CLATHROPROBES project is devoted to the design and development of
novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes
for sensing and structural studies of biomolecules based on cage metal
complexes (clathrochelates and lacunar complexes of spatial
tris-diiminate ligands with encapsulated 3d-metal ion) as molecular
reporters.
For successful design and synthesis of cage metal
complexes (WP1), their complete structural and spectroscopic
characterization (WP2), studies of their interactions with biomolecules
and reporting properties, and their cytotoxicity and bioactivity in
model systems (WP3), the project brings together researchers from four
academic institutions and two industrial companies, representing six
countries (PL, DE, UA, RO and AU; RU - participation till April 8th,
2022). The participants will contribute to the project with different,
highly specific, yet complementary expertise, namely in chemical
synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS
participation till April 8th, 2022), identification and structural
studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS;
INEOS RAS - participation till April 8th, 2022), characterization of
interactions between ligands/clathrochelates/materials and biomolecules
by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR,
UNIVIE, SPS), and biological studies (FAU).
Joint efforts of
participants of this multidisciplinary project will provide - the
transfer of knowledge between scientists of different research areas,
sectors and countries that will enhance level of their professional
scientific/technical expertise, -training of young researchers, very
important for their further scientific success or industrial career, -
enhancement of research activity and network of participating
Institutions, - new long-term collaborations between the partners, -
increase of academia-industry interactions, so valuable for innovative
ideas and discoveries, and pair scientific excellence with social
awareness and understanding of current tasks and problems of science.
The CLATHROPROBES project is devoted to the design and development of
novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes
for sensing and structural studies of biomolecules based on cage metal
complexes (clathrochelates and lacunar complexes of spatial
tris-diiminate ligands with encapsulated 3d-metal ion) as molecular
reporters.
For successful design and synthesis of cage metal
complexes (WP1), their complete structural and spectroscopic
characterization (WP2), studies of their interactions with biomolecules
and reporting properties, and their cytotoxicity and bioactivity in
model systems (WP3), the project brings together researchers from four
academic institutions and two industrial companies, representing six
countries (PL, DE, UA, RO and AU; RU - participation till April 8th,
2022). The participants will contribute to the project with different,
highly specific, yet complementary expertise, namely in chemical
synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS
participation till April 8th, 2022), identification and structural
studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS;
INEOS RAS - participation till April 8th, 2022), characterization of
interactions between ligands/clathrochelates/materials and biomolecules
by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR,
UNIVIE, SPS), and biological studies (FAU).
Joint efforts of
participants of this multidisciplinary project will provide - the
transfer of knowledge between scientists of different research areas,
sectors and countries that will enhance level of their professional
scientific/technical expertise, -training of young researchers, very
important for their further scientific success or industrial career, -
enhancement of research activity and network of participating
Institutions, - new long-term collaborations between the partners, -
increase of academia-industry interactions, so valuable for innovative
ideas and discoveries, and pair scientific excellence with social
awareness and understanding of current tasks and problems of science.