Lehrstuhl für Pharmazeutische Biologie

Restoring cardenolide accumulation in RNAi-mediated DlP5 beta R1 and DlP5 beta R2 knockdown shoot culture lines of Digitalis lanata and studying the effects of precursor feeding on cardenolide free dark-cultured D. lanata shoots (2021) Ignatova A, Klein J, Leykauf T, Kreis W, Munkert J Conference contribution In silico, in vitro, and structural investigations on BAHD-enzymes from different species able to malonylate 21-hydroxypregnanes (2021) Tropper M, Wolf LS, Lanig H, Kreis W Conference contribution FloCan-A Revised Checklist for the Flora of the Canary Islands (2021) Beierkuhnlein C, Walentowitz A, Welß W Journal article 21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata (2021) Tropper M, Höhn S, Wolf LS, Fritsch J, Kastner-Detter N, Rieck C, Munkert J, et al. Journal article, Original article Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells (2021) Zanchett Schneider NF, Menegaz D, Andreotti Dagostin AL, Persich L, Rocha SC, Pacheco Ramos AC, Cortes VF, et al. Journal article RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content (2021) Klein J, Horn E, Ernst M, Leykauf T, Leupold T, Dorfner M, Wolf LS, et al. Journal article Cardenolide and glucosinolate accumulation in shoot cultures of Erysimum crepidifolium Rchb. (2020) Horn E, Kemmler Y, Kreis W, Munkert J Journal article, Original article Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis (2020) Freitas CS, Oliveira-da-Silva JA, Lage DP, Costa RR, Mendonça DV, Martins VT, Reis TA, et al. Journal article Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation (2020) Boff L, Schreiber A, Matos AdR, Del Sarto JL, Brunotte L, Munkert J, Ottoni FM, et al. Journal article, Original article Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells (2020) Boff L, Persich L, Brambila P, Ottoni FM, Munkert J, Ramos GS, Soares Viana AR, et al. Journal article