Romeis S, Hoppe A, Eisermann C, Schneider N, Boccaccini AR, Schmidt J, Peukert W (2014)
Publication Type: Journal article, Original article
Publication year: 2014
Publisher: Wiley-Blackwell
Book Volume: 97
Pages Range: 150-156
Journal Issue: 1
DOI: 10.1111/jace.12615
45S5 Bioglassâ (45S5 BG) is a frequently applied Type A bioactive material, capable of forming an inherent bond to bone and soft tissue. Currently, applied melt-derived bioactive glass powders (BG) exhibit particle sizes between a few to several hundred micrometers. Recent studies on nanometer-sized bioactive glasses (nBGs), produced by bottom-up methods like sol– gel processing or flame spray pyrolysis, have indicated their great potential for several biomedical applications. In this study, the feasibility of top-down processing starting from bulk 45S5 BG by wet comminution in a stirred media mill was investigated. The products were assessed by in vitro hydroxycarbonate apatite (HCAp) formation in simulated body fluid, which is a marker for bioactive behavior. The study reveals the paramount influence of the used solvent for a successful topdown processing: In comparison with the as-received material bioactivity is lost for powders processed in water, preserved for comminution in ethanol and increased for powders processed using the alcohols n-butanol, n-pentanol, and n-hexanol. It was also found that only for the latter solvents, the chemical composition of the glass is maintained during comminution. Flakelike, slightly porous particles with specific surface areas of 25–30 m2/g are obtained. Thus, the presented comminution approach offers a convenient technique to process 45S5 BG with enhanced bioactivity.
APA:
Romeis, S., Hoppe, A., Eisermann, C., Schneider, N., Boccaccini, A.R., Schmidt, J., & Peukert, W. (2014). Enhancing In Vitro Bioactivity of Melt-Derived 45S5 Bioglass® by Comminution in a Stirred Media Mill. Journal of the American Ceramic Society, 97(1), 150-156. https://dx.doi.org/10.1111/jace.12615
MLA:
Romeis, Stefan, et al. "Enhancing In Vitro Bioactivity of Melt-Derived 45S5 Bioglass® by Comminution in a Stirred Media Mill." Journal of the American Ceramic Society 97.1 (2014): 150-156.
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