Swernath S, Kaspereit M, Kienle A (2014)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2014
Book Volume: 37
Pages Range: 643-651
Journal Issue: 4
Combining an enantioseparation by continuous chromatography with the racemization of the undesired enantiomer in a recycle is a promising approach. Two different cases were considered: limited conversion of the reaction with moderate product purity requirements and high conversion with high product purity requirements. For the first case, a simple plantwide control strategy is presented, manipulating the solvent removal in front of the racemization reactor. It is shown that the various disturbances can be compensated with this strategy without performing the more complex readjustment of the chromatographic unit. Further, it is shown that this strategy is likely to fail in the second scenario and that readjustment of the chromatographic unit is required for a successful control strategy. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
APA:
Swernath, S., Kaspereit, M., & Kienle, A. (2014). Coupled continuous chromatography and racemization processes for the production of pure enantiomers. Chemical Engineering & Technology, 37(4), 643-651. https://dx.doi.org/10.1002/ceat.201300597
MLA:
Swernath, Subramanian, Malte Kaspereit, and Achim Kienle. "Coupled continuous chromatography and racemization processes for the production of pure enantiomers." Chemical Engineering & Technology 37.4 (2014): 643-651.
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