Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT

Won J, Takahashi H, Ploner S, Karbole W, Abu-Qamar O, Yaghy A, Marmalidou A, Kaiser S, Hwang Y, Lin J, Witkin A, Desai S, Baumal CR, Maier A, Curcio CA, Waheed NK, Fujimoto JG (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Investigative Ophthalmology & Visual Science Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 65

Article Number: 18

Journal Issue: 10

DOI: 10.1167/iovs.65.10.18

Abstract

PURPOSE. A micrometer scale hyporeflective band within the retinal pigment epithelium basal lamina – Bruch’s membrane complex (RPE-BL-BrM) was topographically measured in aging and age-related macular degeneration (AMD). METHODS. In a prospective cross-sectional study, 90 normal eyes from 76 subjects (range = 23–90 years) and 53 dry AMD eyes from 47 subjects (range = 62–91 years) were enrolled. Isotropic volume raster scans over 6 mm × 6 mm (500 × 500 A-scans) were acquired using a high-resolution (2.7 μm axial resolution) spectral-domain optical coherence tomography (SD-OCT) prototype instrument. Six consecutive optical coherence tomography (OCT) volumes were computationally motion-corrected and fused to improve feature visibility. A boundary regression neural network was developed to measure hyporeflective band thickness. Topographic dependence was evaluated over a 6-mm-diameter Early Treatment Diabetic Retinopathy Study (ETDRS) grid. RESULTS. The hyporeflective band thickness map (median of 4.3 μm and 7.8 μm in normal and AMD eyes, respectively) is thicker below and radially symmetric around the fovea. In normal eyes, age-associated differences occur within 0.7 to 2.3 mm from the foveal center (P < 0.05). In AMD eyes, the hyporeflective band is hypothesized to be basal laminar deposits (BLamDs) and is thicker within the 3-mm ETDRS circle (P < 0.0002) compared with normal eyes. The inner ring is the most sensitive location to detect age versus AMD-associated changes within the RPE-BL-BrM. AMD eyes with subretinal drusenoid deposits (SDDs) have a significantly thicker hyporeflective band (P < 0.001) than those without SDDs. CONCLUSIONS. The hyporeflective band is a quantifiable biomarker which differentiates AMD from aging. Longitudinal studies are warranted. The hyporeflective band may be a useful biomarker for risk stratification and disease progression.

Authors with CRIS profile

Stefan Ploner Lehrstuhl für Informatik 5 (Mustererkennung) Wenke Karbole Lehrstuhl für Informatik 14 (Bild- und Sprachverarbeitung) (LME) Andreas Maier Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Massachusetts Institute of Technology (MIT) US United States (USA) (US) New England Eye Center US United States (USA) (US) University of Alabama at Birmingham (UAB) US United States (USA) (US)

How to cite

APA:

Won, J., Takahashi, H., Ploner, S., Karbole, W., Abu-Qamar, O., Yaghy, A.,... Fujimoto, J.G. (2024). Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT. Investigative Ophthalmology & Visual Science, 65(10). https://doi.org/10.1167/iovs.65.10.18

MLA:

Won, Jungeun, et al. "Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT." Investigative Ophthalmology & Visual Science 65.10 (2024).

BibTeX: Download