Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications
Borges-Vilches J, Ünalan I, Aguayo CR, Fernández K, Boccaccini AR (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 24
Pages Range: 5183-5193
Journal Issue: 11
DOI: 10.1021/acs.biomac.3c00727
Abstract
Chitosan (CS)-based scaffolds loaded with Pinus radiata extract bark (PE) and grape seed extract (GSE) were successfully developed for wound dressing applications. The effects of incorporating GSE and PE in CS scaffolds were investigated in relation to their physicochemical and biological properties. All scaffolds exhibited porous structures with the ability to absorb more than 70 times their weight when contacted with blood and phosphate buffer solution. The incorporation of GSE and PE into the CS scaffolds increased their blood absorption ability and degradation rates over time. All scaffolds showed a clotting ability above 95%, with their surfaces being favorable for red blood cell attachment. Both GSE and PE were released from the CS scaffolds in a sustained manner. Scaffolds loaded with GSE and PE inhibited the bacterial activity of S. aureus and E. coli by 40% and 44% after 24 h testing. In vitro cell viability studies demonstrated that all scaffolds were nontoxic to HaCaT cells. Importantly, the addition of GSE and PE further increased cell viability compared to that of the CS scaffold. This study provides a new synthesis method to immobilize GSE and PE on CS scaffolds, enabling the formation of novel material platforms with a high potential for wound dressing applications.
Authors with CRIS profile
Irem Ünalan
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Chile (CL)How to cite
APA:
Borges-Vilches, J., Ünalan, I., Aguayo, C.R., Fernández, K., & Boccaccini, A.R. (2023). Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications. Biomacromolecules, 24(11), 5183-5193. https://dx.doi.org/10.1021/acs.biomac.3c00727
MLA:
Borges-Vilches, Jessica, et al. "Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications." Biomacromolecules 24.11 (2023): 5183-5193.
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