Occurrence and conversion of progestogens and androgens are conserved in land plants

Shiko G, Paulmann MJ, Feistel F, Ntefidou M, Hermann-Ene V, Vetter W, Kost B, Kunert G, Zedler JA, Reichelt M, Oelmüller R, Klein J (2023)

Publication Type: Journal article

Publication year: 2023

Journal

New Phytologist Wiley-Blackwell

DOI: 10.1111/nph.19163

Abstract

Progestogens and androgens have been found in many plants, but little is known about their biosynthesis and the evolution of steroidogenesis in these organisms. Here, we show that the occurrence and biosynthesis of progestogens and androgens are conserved across the viridiplantae lineage. An UHPLC-ESI-MS/MS method allowed high-throughput analysis of the occurrence and chemical conversion of progestogens and androgens in 41 species across the green plant lineage. Dehydroepiandrosterone, testosterone, and 5α-dihydrotestosterone are plants' most abundant mammalian-like steroids. Progestogens are converted into 17α-hydroxyprogesterone and 5α-pregnane-3,20-dione. Androgens are converted into testosterone and 5α-dihydrotestosterone. 17,20-Lyases, essential for converting progestogens to androgens, seem to be most effective in monocot species. Our data suggest that the occurrence of progestogens and androgens is highly conserved in plants, and their biosynthesis might favor a route using the Δ4 pathway.

Authors with CRIS profile

Maria Ntefidou Lehrstuhl für Zellbiologie Benedikt Kost Lehrstuhl für Zellbiologie

Involved external institutions

Friedrich-Schiller-Universität Jena DE Germany (DE) Max-Planck-Institut für chemische Ökologie / Max Planck Institute for Chemical Ecology DE Germany (DE) Universität Hohenheim DE Germany (DE)

How to cite

APA:

Shiko, G., Paulmann, M.J., Feistel, F., Ntefidou, M., Hermann-Ene, V., Vetter, W.,... Klein, J. (2023). Occurrence and conversion of progestogens and androgens are conserved in land plants. New Phytologist. https://dx.doi.org/10.1111/nph.19163

MLA:

Shiko, Glendis, et al. "Occurrence and conversion of progestogens and androgens are conserved in land plants." New Phytologist (2023).

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