High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production

Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte V, Wirtz S, Tanaka Y, Winkler T, Schett G, Soulat D, Bozec A (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 42

Article Number: 112713

Journal Issue: 7

DOI: 10.1016/j.celrep.2023.112713

Abstract

Although it is known that psoriasis is strongly associated with obesity, the mechanistic connection between diet and skin lesions is not well established. Herein, we showed that only dietary fat, not carbohydrates or proteins, exacerbates psoriatic disease. Enhanced psoriatic skin inflammation was associated with changes in the intestinal mucus layer and microbiota composition by high-fat diet (HFD). Change of intestinal microbiota by vancomycin treatment effectively blocked activation of psoriatic skin inflammation by HFD, inhibited the systemic interleukin-17 (IL-17) response, and led to increased mucophilic bacterial species such as Akkermansia muciniphila. By using IL-17 reporter mice, we could show that HFD facilitates IL-17-mediated γδ T cell response in the spleen. Notably, oral gavage with live or heat-killed A. muciniphila effectively inhibited HFD-induced enhancement of psoriatic disease. In conclusion, HFD exacerbates psoriatic skin inflammation through changing the mucus barrier and the intestine microbial composition, which leads to an enhanced systemic IL-17 response.

Authors with CRIS profile

Rui Song Department of Medicine 3 – Rheumatology and Immunology Anne Maria Hahn Lehrstuhl für Genetik Xianyi Meng Juniorprofessur für Osteoimmunologie Pang Lyu Professur für Experimentelle Immuntherapie Shan Cao Juniorprofessur für Osteoimmunologie Ning Liu Professur für Experimentelle Immuntherapie Verena Taudte Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Stefan Wirtz Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Thomas Winkler Professur für Genetik Georg Schett Lehrstuhl für Innere Medizin III Didier Soulat Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Aline Bozec Juniorprofessur für Osteoimmunologie

Involved external institutions

University of Occupational and Environmental Health Japan / 産業医科大学 JP Japan (JP)

How to cite

APA:

Sonomoto, K., Song, R., Eriksson, D., Hahn, A.M., Meng, X., Lyu, P.,... Bozec, A. (2023). High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production. Cell Reports, 42(7). https://dx.doi.org/10.1016/j.celrep.2023.112713

MLA:

Sonomoto, Koshiro, et al. "High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production." Cell Reports 42.7 (2023).

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