Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system

Reinelt M, Ahlfs J, Stein R, Alexiou C, Bänsch E, Friedrich RP, Lyer S, Neuß M, Neuß N (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Journal of Magnetism and Magnetic Materials Elsevier

Book Volume: 582

Article Number: 170984

DOI: 10.1016/j.jmmm.2023.170984

Abstract

In this paper, a mathematical model for the dynamics of superparamagnetic iron oxide nanoparticles (SPIONs) in a laminar flow through a pipe under the influence of an external magnetic field of a single electromagnet is derived. The model consists of a convection–diffusion equation coupled with magnetostatic equations. The accumulation of particles along the boundary is modeled with the help of a surface concentration. Based on experimental data describing the retention of lauric acid coated SPIONs in a tubular flow under the influence of a magnetic field, the model is parametrized and finite element simulations are performed. With the exception of one outlier at low SPION concentration and high flowspeed, the simulation results agree very well with the experimental measurements within the bounds of the measurement error.

Authors with CRIS profile

Magdalena Reinelt Economics - Discrete Optimization - Mathematics (EDOM) Johannes Ahlfs Professur für Nanomedizin René Stein Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin Eberhard Bänsch Lehrstuhl für Angewandte Mathematik (Wissenschaftliches Rechnen) Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Maria Neuß Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik) Nicolas Neuß Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik)

How to cite

APA:

Reinelt, M., Ahlfs, J., Stein, R., Alexiou, C., Bänsch, E., Friedrich, R.P.,... Neuß, N. (2023). Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system. Journal of Magnetism and Magnetic Materials, 582. https://doi.org/10.1016/j.jmmm.2023.170984

MLA:

Reinelt, Magdalena, et al. "Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system." Journal of Magnetism and Magnetic Materials 582 (2023).

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