Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Culemann S, Knab K, Euler M, Wegner A, Garibagaoglu H, Ackermann J, Fischer K, Kienhoefer D, Crainiciuc G, Hahn J, Grüneboom A, Nimmerjahn F, Uderhardt S, Hidalgo A, Schett G, Hoffmann M, Krönke G (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Journal of Experimental Medicine Rockefeller University Press

Book Volume: 220

Journal Issue: 6

DOI: 10.1084/jem.20220525

Abstract

The authors show that the anti-inflammatory effects of clodronate liposomes do not result from the depletion of mononuclear phagocytes but from a functional stunning of polymorphonuclear neutrophils. These findings necessitate a critical revision of the current literature on the role of monocytes and macrophages in inflammation.

Authors with CRIS profile

Katharina Knab Department of Medicine 3 – Rheumatology and Immunology Maximilien Euler Department of Medicine 3 – Rheumatology and Immunology Anja Wegner Department of Medicine 3 – Rheumatology and Immunology Hilal Garibagaoglu Department of Medicine 3 – Rheumatology and Immunology Jochen Ackermann Department of Medicine 3 – Rheumatology and Immunology Jonas Hahn Department of Medicine 3 – Rheumatology and Immunology Falk Nimmerjahn Lehrstuhl für Genetik Stefan Uderhardt Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Markus Hoffmann Medizinische Fakultät Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung FAU Profilzentrum Licht.Materie.Quantentechnologien (FAU LMQ)

Related research project(s)

A086: Role of synovial macrophage subsets during inflammatory arthritis June 16, 2020 - June 15, 2023

Involved external institutions

Spanish National Center for Cardiovascular Research / Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ES Spain (ES)

How to cite

APA:

Culemann, S., Knab, K., Euler, M., Wegner, A., Garibagaoglu, H., Ackermann, J.,... Krönke, G. (2023). Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. Journal of Experimental Medicine, 220(6). https://dx.doi.org/10.1084/jem.20220525

MLA:

Culemann, Stephan, et al. "Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes." Journal of Experimental Medicine 220.6 (2023).

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