A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Hahn AM, Vogg L, Brey S, Schneider A, Schäfer S, Palmisano R, Pavlova A, Sandrock I, Tan L, Fichtner AS, Prinz I, Ravens S, Winkler T (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 42

Pages Range: 112558

Article Number: 112253

Journal Issue: 3

DOI: 10.1016/j.celrep.2023.112253

Abstract

The clonal selection theory describes key features of adaptive immune responses of B and T cells. For αβ T cells and B cells, antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in γδ T cells remains less well understood. To better understand the role of the γδ T cell receptor (TCR), we generate an orthotopic TCRδ transgenic mouse model. We demonstrate a multi-layered functionality of γδ TCRs and diverse roles of CDR3δ-mediated selection during γδ T cell development. Whereas epithelial populations using Vγ5 or Vγ7 chains are almost unaffected in their biology in the presence of the transgenic TCRδ chain, pairing with Vγ1 positively selects γδ T cell subpopulations with distinct programs in several organs, thereby distorting the repertoire. In conclusion, our data support dictation of developmental tropism together with adaptive-like recognition principles in a single antigen receptor.

Authors with CRIS profile

Anne Maria Hahn Lehrstuhl für Genetik Lisa Vogg Professur für Genetik Stefanie Brey Lehrstuhl für Genetik Andrea Schneider Lehrstuhl für Genetik Simon Schäfer Lehrstuhl für Genetik Ralf Palmisano FAU Optical Imaging Competence Center (FAU OICE) Anna Pavlova Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Thomas Winkler Professur für Genetik

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung FAU Profilzentrum Licht.Materie.Quantentechnologien (FAU LMQ)

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Hahn, A.M., Vogg, L., Brey, S., Schneider, A., Schäfer, S., Palmisano, R.,... Winkler, T. (2023). A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages. Cell Reports, 42(3), 112558. https://dx.doi.org/10.1016/j.celrep.2023.112253

MLA:

Hahn, Anne Maria, et al. "A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages." Cell Reports 42.3 (2023): 112558.

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