Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates

Motola M, Capek J, Zazpe R, Bacova J, Hromadko L, Bruckova L, Ng SW, Handl J, Spotz Z, Knotek P, Baishya K, Majtnerova P, Prikryl J, Sopha H, Rousar T, Macak JM (2020)

Publication Type: Journal article

Publication year: 2020

Journal

ACS Applied Bio Materials American Chemical Society

Book Volume: 3

Pages Range: 6447-6456

Journal Issue: 9

DOI: 10.1021/acsabm.0c00871

Abstract

The present work exploits Ti sheets and TiO2 nanotube (TNT) layers and their surface modifications for the proliferation of different cells. Ti sheets with a native oxide layer, Ti sheets with a crystalline thermal oxide layer, and two kinds of TNT layers (prepared via electrochemical anodization) with a defined inner diameter of 12 and 15 nm were used as substrates. A part of the Ti sheets and the TNT layers was additionally coated by thin TiO2 coatings using atomic layer deposition (ALD). An increase in cell growth of WI-38 fibroblasts (>50%), MG-63 osteoblasts (>30%), and SH-SY5Y neuroblasts (>30%) was observed for all materials coated by five cycles ALD compared to their uncoated counterparts. The additional ALD TiO2 coatings changed the surface composition of all materials but preserved their original structure and protected them from unwanted crystallization and shape changes. The presented approach of mild surface modification by ALD has a significant effect on the materials' biocompatibility and is promising toward application in implant materials.

Authors with CRIS profile

Siow Woon Ng

Involved external institutions

University of Pardubice CZ Czech Republic (CZ) Brno University of Technology (BUT) / Vysoké učení technické v Brně (VUT) CZ Czech Republic (CZ)

How to cite

APA:

Motola, M., Capek, J., Zazpe, R., Bacova, J., Hromadko, L., Bruckova, L.,... Macak, J.M. (2020). Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates. ACS Applied Bio Materials, 3(9), 6447-6456. https://doi.org/10.1021/acsabm.0c00871

MLA:

Motola, Martin, et al. "Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates." ACS Applied Bio Materials 3.9 (2020): 6447-6456.

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