Photochromic Fentanyl Derivatives for Controlled mu-Opioid Receptor Activation

Lahmy R, Hübner H, Schmidt M, Lachmann D, Gmeiner P, König B (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Chemistry - A European Journal Wiley

DOI: 10.1002/chem.202201515

Abstract

Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant mu-opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have been developed in this work, modelled on the known agonist fentanyl, with the aim of expanding the current "toolbox" of fentanyl photoswitchable ligands. In doing so, ligands have been developed that change geometry (isomerize) upon exposure to light, with varying photophysical and biochemical properties. This variation in properties could be valuable in further studying the functional significance of the mu-opioid receptor.

Authors with CRIS profile

Harald Hübner Lehrstuhl für Pharmazeutische Chemie Maximilian Schmidt Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

Involved external institutions

Universität Regensburg DE Germany (DE)

How to cite

APA:

Lahmy, R., Hübner, H., Schmidt, M., Lachmann, D., Gmeiner, P., & König, B. (2022). Photochromic Fentanyl Derivatives for Controlled mu-Opioid Receptor Activation. Chemistry - A European Journal. https://dx.doi.org/10.1002/chem.202201515

MLA:

Lahmy, Ranit, et al. "Photochromic Fentanyl Derivatives for Controlled mu-Opioid Receptor Activation." Chemistry - A European Journal (2022).

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