TUMOR-DERIVED GDF-15 PREVENTS THERAPY SUCCESS OF CHECKPOINT INHIBITORS BY BLOCKING T-LYMPHOCYTE RECRUITMENT
Haake M, Schaefer T, Haack B, Vashist N, Genssler S, Harter P, Martens A, Wistuba-Hamprecht K, Wedekink F, Fischer B, Mittelbronn M, Levesque M, Cheng P, Dummer R, Weide B, Klar K, Leo E, Nimmerjahn F, Schuberth-Wagner C, Wischhusen J (2021)
Publication Type: Conference contribution
Publication year: 2021
Journal
Publisher: BMJ PUBLISHING GROUP
City/Town: LONDON
Pages Range: A597-A597
Conference Proceedings Title: JOURNAL FOR IMMUNOTHERAPY OF CANCER
DOI: 10.1136/jitc-2021-SITC2021.568
Abstract
Immune checkpoint blockade (ICB) can achieve durable responses in a subgroup of patients with metastatic cancer, only. Poor immune effector cell infiltration into the tumor microenvironment is a major obstacle to successful therapy. Growth and differentiation factor 15 (GDF-15) is a divergent member of the TGF-β superfamily and has been linked to feto-maternal tolerance, anorexia but recently also to potent local immunosuppression under physiologic and pathophysiologic conditions. GDF-15 is overexpressed in a wide variety of tumors and may be key factor produced by tumors to prevent effective immune cell infiltration into the tumor and to potently block checkpoint inhibitor activity.
Authors with CRIS profile
Involved external institutions
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Universitätsspital Zürich (USZ)
Switzerland (CH)
Universitätsklinikum Würzburg
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
CatalYm GmbH
Germany (DE)
University of Luxembourg
Luxembourg (LU)
Germany (DE)
Universitätsspital Zürich (USZ)
Switzerland (CH)
Universitätsklinikum Würzburg
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
CatalYm GmbH
Germany (DE)
University of Luxembourg
Luxembourg (LU)
How to cite
APA:
Haake, M., Schaefer, T., Haack, B., Vashist, N., Genssler, S., Harter, P.,... Wischhusen, J. (2021). TUMOR-DERIVED GDF-15 PREVENTS THERAPY SUCCESS OF CHECKPOINT INHIBITORS BY BLOCKING T-LYMPHOCYTE RECRUITMENT. In JOURNAL FOR IMMUNOTHERAPY OF CANCER (pp. A597-A597). LONDON: BMJ PUBLISHING GROUP.
MLA:
Haake, Markus, et al. "TUMOR-DERIVED GDF-15 PREVENTS THERAPY SUCCESS OF CHECKPOINT INHIBITORS BY BLOCKING T-LYMPHOCYTE RECRUITMENT." Proceedings of the JOURNAL FOR IMMUNOTHERAPY OF CANCER LONDON: BMJ PUBLISHING GROUP, 2021. A597-A597.
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