Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society

Kroke A, Schmidt A, Amini AM, Kalotai N, Lehmann A, Haardt J, Bauer JM, Bischoff-Ferrari HA, Boeing H, Egert S, Ellinger S, Kuhn T, Louis S, Lorkowski S, Nimptsch K, Remer T, Schulze MB, Siener R, Stangl G, Volkert D, Zittermann A, Buyken AE, Watzl B, Schwingshackl L (2022)

Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1007/s00394-021-02789-5

Abstract

Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods: A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results: The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion: The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake.

Authors with CRIS profile

Involved external institutions

Deutsche Gesellschaft für Ernährung e.V. Germany (DE) Universitätsspital Zürich (USZ) Switzerland (CH) Max-Rubner-Institut - Bundesforschungsinstitut für Ernährung und Lebensmittel Germany (DE) Queen's University United Kingdom (GB) Martin-Luther-Universität Halle-Wittenberg (MLU) Germany (DE) Universitätsklinikum Bonn Germany (DE) Friedrich-Schiller-Universität Jena Germany (DE) Universität Paderborn Germany (DE) Hochschule Fulda Germany (DE) Herz- und Diabeteszentrum Nordrhein-Westfalen Germany (DE) Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Deutsches Institut für Ernährungsforschung (DIfE) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE)

How to cite

APA:

Kroke, A., Schmidt, A., Amini, A.M., Kalotai, N., Lehmann, A., Haardt, J.,... Schwingshackl, L. (2022). Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society. European Journal of Nutrition. https://dx.doi.org/10.1007/s00394-021-02789-5

MLA:

Kroke, Anja, et al. "Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society." European Journal of Nutrition (2022).

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