Experimental Investigation and Modeling of Cocrystal Formation in L-Menthol/Thymol Eutectic System

Alhadid A, Jandl C, Mokrushina L, Minceva M (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Crystal Growth and Design American Chemical Society

Abstract

Solid-liquid equilibria (SLE) of the l-menthol/thymol eutectic system were studied in detail using a combination of differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). The existence of two cocrystals with stoichiometric ratios 1:3 and 3:2 for l-menthol:thymol was monitored by performing XRD on samples of different compositions. Moreover, the existence of two solid solution regions of l-menthol in thymol and l-menthol in the 1:3 cocrystal was observed. The nonrandom two-liquid (NRTL) and two-suffix Margules models were applied to model the measured SLE data. The two eutectic points of the system were determined at Te1cal = 271.7 K, xthymol,e1cal = 0.48 and Te2cal = 273.1 K, xthymol,e2cal = 0.33. The complex character of the obtained phase diagram of the system shows that not all deep eutectic systems can be assumed to be of a simple eutectic type with immiscible solid phases. For the accurate determination of the SLE of eutectic systems, a combination of several experimental techniques and thermodynamic modeling is needed.

Authors with CRIS profile

Liudmila Mokrushina Lehrstuhl für Thermische Verfahrenstechnik

Involved external institutions

Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt

Germany (DE) Technische Universität München (TUM)

Germany (DE)

How to cite

APA:

Alhadid, A., Jandl, C., Mokrushina, L., & Minceva, M. (2021). Experimental Investigation and Modeling of Cocrystal Formation in L-Menthol/Thymol Eutectic System. Crystal Growth and Design. https://dx.doi.org/10.1021/acs.cgd.1c00306

MLA:

Alhadid, Ahmad, et al. "Experimental Investigation and Modeling of Cocrystal Formation in L-Menthol/Thymol Eutectic System." Crystal Growth and Design (2021).

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