Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization

Rincón-López JA, Hermann-Muñoz JA, Cinca-Luis N, Fernández-Benavides DA, García-Cano I, Guilemany-Casadamon JM, Boccaccini AR, Muñoz-Saldaña J, Alvarado-Orozco JM (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of the European Ceramic Society Elsevier

DOI: 10.1016/j.jeurceramsoc.2021.07.058

Abstract

The ability of the Nagelschmidtite (Nagel) phase to promote osteogenesis, cementogenesis, and angiogenesis increased the interest in using this calcium silicophosphate bioceramic for tissue regeneration and vascularization applications. Nagel phase is a solid solution with the general formula Ca7-xNax(PO4)2+x(SiO4)2-x, which allows several substitutions being Ca7(PO4)2(SiO4)2 the most reported stoichiometry. Inspired by the well-known 45S5 bioactive glass chemical composition, we developed a synthesis route to obtain a Na-rich Nagel single phase. The effect of this bioceramic chemical and structural properties on apatite formation and crystallization mechanism is reported. The structural aspects at the nano and microscale of the mechanism of apatite growth and crystallization from the Nagel phase were compared to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems, revealing a biomimetic behavior during the apatite biomineralization process from the bioceramic.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Center for Research and Advanced Studies of the National Polytechnic Institute / Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN) MX Mexico (MX) Universitat de Barcelona (UB) / University of Barcelona ES Spain (ES) Consorcio de Manufactura Aditiva (CONMAD) MX Mexico (MX)

How to cite

APA:

Rincón-López, J.A., Hermann-Muñoz, J.A., Cinca-Luis, N., Fernández-Benavides, D.A., García-Cano, I., Guilemany-Casadamon, J.M.,... Alvarado-Orozco, J.M. (2021). Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization. Journal of the European Ceramic Society. https://dx.doi.org/10.1016/j.jeurceramsoc.2021.07.058

MLA:

Rincón-López, July Andrea, et al. "Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization." Journal of the European Ceramic Society (2021).

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