Barboni MTS, Dias SL, Silva LA, Damico FM, Vidal KS, Costa MF, Nagy BV, Kremers J, Ventura DF (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 62
Article Number: 29
Journal Issue: 4
DOI: 10.1167/iovs.62.4.29
PURPOSE. The purpose of this study was to characterize changes in the full-field flash electroretinogram (ERG) in association with psychophysical dark-adapted visual thresholds in patients with genetically characterized Duchenne muscular dystrophy (DMD) either lacking Dp427 (Up 30) or at least Dp260 in addition to Dp427 (Down 30). METHODS. Twenty-one patients with DMD and 27 age-similar controls participated in this study. Dark-adapted (0.01, 3.0, and 10 cd.s/m2 flashes) and light-adapted (3.0 cd.s/m2 flash) ERGs were recorded following International Society for Clinical Electrophysiology of Vision (ISCEV) standard protocols. Visual detection thresholds to 625-nm (cone function) and 527-nm (rod function) light-emitting diode (LED) flashes (2 degree diameter) were measured during a dark adaptation period after a 1-minute exposure to a bleaching light (3000 cd/m2). Initially, 8 minutes of interleaved 625-nm and 527-nm thresholds were measured. After an additional 5 minutes of dark-adaptation, a second set of threshold measurements to 527-nm stimuli was performed during the subsequent 6 minutes. RESULTS. Dark-adapted b-wave amplitude was significantly reduced to all strengths of flash and a-wave in response to the strong flash stimulus was delayed (15.6 vs. 14.7 ms, P < 0.05) in patients with Down 30 compared with controls. Dark-adapted cone thresholds did not differ among the groups (−2.0, −1.8, and −1.7 log cd/m2 for Down 30, Up 30, and controls, respectively, P = 0.21). In contrast, dark-adapted rod thresholds were elevated (F
APA:
Barboni, M.T.S., Dias, S.L., Silva, L.A., Damico, F.M., Vidal, K.S., Costa, M.F.,... Ventura, D.F. (2021). Correlations between dark-adapted rod threshold elevations and erg response deficits in duchenne muscular dystrophy. Investigative Ophthalmology & Visual Science, 62(4). https://doi.org/10.1167/iovs.62.4.29
MLA:
Barboni, Mirella Telles Salgueiro, et al. "Correlations between dark-adapted rod threshold elevations and erg response deficits in duchenne muscular dystrophy." Investigative Ophthalmology & Visual Science 62.4 (2021).
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