Amphiregulin Regulates Melanocytic Senescence

Pommer M, Kuphal S, Boßerhoff AK (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Cells MDPI

Book Volume: 10

Journal Issue: 2

DOI: 10.3390/cells10020326

Abstract

Oncogene-induced senescence (OIS) is a decisive process to suppress tumor development, but the molecular details of OIS are still under investigation. Using an established OIS model of primary melanocytes transduced with BRAF V600E and compared to control cells, amphiregulin (AREG) was shown to be induced. In addition, AREG expression was observed in nevi, which by definition, are senescent cell clusters, compared to melanocytes. Interestingly, treatment of melanocytes with recombinant AREG did induce senescence. This led to the assumption that extracellular AREG has an important function in this process. Inhibition of the epidermal growth factor receptor (EGFR) using Gefitinib identified AREG as one of EGFR ligands responsible for senescence. Furthermore, depletion of AREG expression in senescent BRAF V600E melanocytes resulted in a significant reduction of senescent melanocytes. This study reveals AREG as an essential molecular component of signaling pathways leading to senescence in melanocytes.

Authors with CRIS profile

Michaela Pommer Lehrstuhl für Biochemie und Molekulare Medizin Silke Kuphal Medizinische Fakultät Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

D031 (Biochemie u. Mol. Medizin: Modulation of oncogene-induced senescence by cell-matrix adhesion March 16, 2020 - March 15, 2023

How to cite

APA:

Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2021). Amphiregulin Regulates Melanocytic Senescence. Cells, 10(2). https://dx.doi.org/10.3390/cells10020326

MLA:

Pommer, Michaela, Silke Kuphal, and Anja Katrin Boßerhoff. "Amphiregulin Regulates Melanocytic Senescence." Cells 10.2 (2021).

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