Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner

Gresing LJ, Radon P, Friedrich RP, Zahn D, Raasch M, Mosig AS, Dutz S, Alexiou C, Wiekhorst F, Hochhaus A, Clement JH (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of Magnetism and Magnetic Materials Elsevier

Book Volume: 521

Article Number: 167535

DOI: 10.1016/j.jmmm.2020.167535

Abstract

The transfer of substances via the blood-placenta barrier is tightly regulated and critical for the fetus and the expecting mother. In case of necessary medical interventions during pregnancy a comprehensive knowledge about the interaction of the drugs with this barrier is indispensable. Therefore well-engineered test systems are needed and valuable transport systems are helpful. We developed an in vitro microfluidic blood-placenta barrier system consisting of the human trophoblast cell line BeWo and human primary placental pericytes. The integrity and stability of the model was verified by a permeability assay and immunocytochemistry. As potential drug carriers magnetic nanoparticles with various coatings were applied and their ability to pass the barrier was quantified by magnetic particle spectroscopy. We could demonstrate that up to 4% of negatively charged nanoparticles pass the barrier in a time-dependent manner.

Authors with CRIS profile

Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Universitätsklinikum Jena DE Germany (DE) Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE) Technische Universität Ilmenau DE Germany (DE)

How to cite

APA:

Gresing, L.J., Radon, P., Friedrich, R.P., Zahn, D., Raasch, M., Mosig, A.S.,... Clement, J.H. (2021). Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner. Journal of Magnetism and Magnetic Materials, 521. https://doi.org/10.1016/j.jmmm.2020.167535

MLA:

Gresing, Lennart J., et al. "Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner." Journal of Magnetism and Magnetic Materials 521 (2021).

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