Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
Wessler S, Schneider G, Backert S (2017)
Publication Type: Journal article, Review article
Publication year: 2017
Journal
Book Volume: 15
Article Number: 4
Journal Issue: 1
DOI: 10.1186/s12964-017-0162-5
Abstract
Recent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseases. HtrA activity enhances bacterial survival under stress conditions, but also has direct effects on functions of the cell adhesion protein E-cadherin and extracellular matrix proteins, including fibronectin and proteoglycans. Although HtrA cannot be considered as a pathogenic factor per se, it exhibits favorable characteristics making HtrA a potentially attractive drug target to combat various bacterial infections.
Authors with CRIS profile
Involved external institutions
Universität Salzburg (Paris Lodron Universität Salzburg)
Austria (AT)
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
Austria (AT)
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
How to cite
APA:
Wessler, S., Schneider, G., & Backert, S. (2017). Bacterial serine protease HtrA as a promising new target for antimicrobial therapy? Cell Communication and Signaling, 15(1). https://dx.doi.org/10.1186/s12964-017-0162-5
MLA:
Wessler, Silja, Gisbert Schneider, and Steffen Backert. "Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?" Cell Communication and Signaling 15.1 (2017).
BibTeX: Download