Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization

Distler T, Fournier N, Grünewald A, Polley C, Seitz H, Detsch R, Boccaccini AR (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Frontiers in Bioengineering and Biotechnology Frontiers Media

Book Volume: 8

Article Number: 552

DOI: 10.3389/fbioe.2020.00552

Abstract

Critical size bone defects are regularly treated by auto- and allograft transplantation. However, such treatments require to harvest bone from patient donor sites, with often limited tissue availability or risk of donor site morbidity. Not requiring bone donation, three-dimensionally (3D) printed implants and biomaterial-based tissue engineering (TE) strategies promise to be the next generation therapies for bone regeneration. We present here polylactic acid (PLA)-bioactive glass (BG) composite scaffolds manufactured by fused deposition modeling (FDM), involving the fabrication of PLA-BG composite filaments which are used to 3D print controlled open-porous and osteoinductive scaffolds. We demonstrated the printability of PLA-BG filaments as well as the bioactivity and cytocompatibility of PLA-BG scaffolds using pre-osteoblast MC3T3E1 cells. Gene expression analyses indicated the beneficial impact of BG inclusions in FDM scaffolds regarding osteoinduction, as BG inclusions lead to increased osteogenic differentiation of human adipose-derived stem cells in comparison to pristine PLA. Our findings confirm that FDM is a convenient additive manufacturing technology to develop PLA-BG composite scaffolds suitable for bone tissue engineering.

Authors with CRIS profile

Thomas Distler Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Alina Grünewald Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universität Rostock DE Germany (DE)

How to cite

APA:

Distler, T., Fournier, N., Grünewald, A., Polley, C., Seitz, H., Detsch, R., & Boccaccini, A.R. (2020). Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization. Frontiers in Bioengineering and Biotechnology, 8. https://dx.doi.org/10.3389/fbioe.2020.00552

MLA:

Distler, Thomas, et al. "Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization." Frontiers in Bioengineering and Biotechnology 8 (2020).

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