Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Braga Emidio N, Baik H, Lee D, Stürmer R, Heuer J, Elliott AG, Blaskovich MA, Haupenthal K, Tegtmeyer N, Hoffmann W, Schroeder CI, Muttenthaler M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Chemical Communications Royal Society of Chemistry

Book Volume: 56

Pages Range: 6420-6423

Journal Issue: 47

DOI: 10.1039/d0cc02321c

Abstract

TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of action remains poorly understood with synthetic intractability a recognised bottleneck. Here we describe the synthesis of TFF1 and its homodimer and their interactions with mucins andHelicobacter pylori. Synthetic access to TFF1 is an important milestone for probe and therapeutic development.

Authors with CRIS profile

Nicole Tegtmeyer-Backert Lehrstuhl für Mikrobiologie

Involved external institutions

University of Queensland AU Australia (AU) Universität Wien / University of Vienna AT Austria (AT) Otto-von-Guericke-Universität Magdeburg DE Germany (DE)

How to cite

APA:

Braga Emidio, N., Baik, H., Lee, D., Stürmer, R., Heuer, J., Elliott, A.G.,... Muttenthaler, M. (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56(47), 6420-6423. https://dx.doi.org/10.1039/d0cc02321c

MLA:

Braga Emidio, Nayara, et al. "Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action." Chemical Communications 56.47 (2020): 6420-6423.

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