The multiple stages towards crystal formation of L-glutamic acid

Trinh H, Khuu CQ, Wolf S, Nguyen AT (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Crystal Growth Elsevier

Book Volume: 544

Article Number: 125727

DOI: 10.1016/j.jcrysgro.2020.125727

Abstract

Governing polymorph selection is a crucial issue in the pharmaceutical, food, and fine chemical industry. However, the multiple stages during the formation of the polymorphic crystals from solution and the concurrent processes selecting the final polymorph are still unclear. In this study, we demonstrate the existence of hydrated amorphous intermediates in the early stages of separation of organic crystal L-glutamic acid where the nucleation of crystalline metastable α-form spontaneously occurred within these intermediates, leading to the formation of odd-shaped and intergrown crystal aggregates. Further, we found that these amorphous intermediates severed not only as a transient intermediate in a nucleation process, but they also co-determined the size distribution, mean particle size, and phase transformation rates of polymorphic L-glutamic acid.

Authors with CRIS profile

Huyen Trinh Juniorprofessur für Werkstoffwissenschaften (Biomimetische Materialien und Prozesse) Stephan Wolf Juniorprofessur für Werkstoffwissenschaften (Biomimetische Materialien und Prozesse) Anh Tuan Nguyen Lehrstuhl für Informatik 14 (Machine Learning and Data Analytics)

Additional Organisation(s)

Machine Learning and Data Analytics Lab

Involved external institutions

Vietnam Academy of Science and Technology VN Viet Nam (VN)

How to cite

APA:

Trinh, H., Khuu, C.Q., Wolf, S., & Nguyen, A.T. (2020). The multiple stages towards crystal formation of L-glutamic acid. Journal of Crystal Growth, 544. https://doi.org/10.1016/j.jcrysgro.2020.125727

MLA:

Trinh, Huyen, et al. "The multiple stages towards crystal formation of L-glutamic acid." Journal of Crystal Growth 544 (2020).

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