Concentrations of N epsilon-Carboxymethyllysine in Human Breast Milk, Infant Formulas, and Urine of Infants
Dittrich R, Hoffmann I, Stahl P, Müller A, Beckmann M, Pischetsrieder M (2006)
Publication Type: Journal article
Publication year: 2006
Journal
Publisher: American Chemical Society
Book Volume: 54
Pages Range: 6924-6928
URI: http://pubs.acs.org/cgi-bin/download.pl?jf060905h/C4tL
DOI: 10.1021/jf060905h
Abstract
Maillard products, such as Nε-carboxymethyllysine (CML), are readily formed during the manufacturing of infant formulas. Little has been known, however, about the presence of CML in human breast milk and about the uptake of CML by infants. In this study, CML was measured in the serum and breast milk of 32 healthy mothers by ELISA. CML concentrations in breast milk (137 ± 82.7 ng/mL) were significantly lower than in the serum (399 ± 67.8 ng/mL, p < 0.001) and on average 35-fold lower than in infant formulas (4754 ± 4299.5 ng/mL). CML was also measured in the urine of 21 infants, which were fed with breast milk or formulas. Although there was a tendency toward higher urinary CML excretion in infants fed with hypoallergenic formulas compared to breast-fed ones, the differences were not significant. Neonates that were delivered by vaginal birth had significantly higher concentrations of CML compared to those delivered by caesarean section (1306 ± 653 vs 601 ± 220 ng/mL, p = 0.012). It is conclued that CML passes from the serum into the breast milk, but the levels are by far lower than in infant formulas. In very young neonates (≤3 days), the mode of delivery has a greater influence on urinary CML excretion than the nutrition. © 2006 American Chemical Society.
Authors with CRIS profile
Ralf Dittrich
Professur für Experimentelle Reproduktionsmedizin
Matthias Beckmann
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Monika Pischetsrieder
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Dittrich, R., Hoffmann, I., Stahl, P., Müller, A., Beckmann, M., & Pischetsrieder, M. (2006). Concentrations of N epsilon-Carboxymethyllysine in Human Breast Milk, Infant Formulas, and Urine of Infants. Journal of Agricultural and Food Chemistry, 54, 6924-6928. https://doi.org/10.1021/jf060905h
MLA:
Dittrich, Ralf, et al. "Concentrations of N epsilon-Carboxymethyllysine in Human Breast Milk, Infant Formulas, and Urine of Infants." Journal of Agricultural and Food Chemistry 54 (2006): 6924-6928.
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