Partition Coefficients of Alkyl Parabens and Ibuprofen in Micellar Systems
Wille S, Mokrushina L, Smirnova I, Arlt W (2010)
Publication Status: Published
Publication Type: Journal article
Publication year: 2010
Journal
Publisher: Wiley-VCH Verlag
Book Volume: 33
Pages Range: 2095-2101
Journal Issue: 12
Abstract
The partitioning of alkyl parabens and ibuprofen in aqueous solutions of nonionic and ionic surfactants is studied experimentally and via a priori predictions using the COSMO-RS model. The effects of organic (Bu(4)NBr) and inorganic (NaCl) electrolytes are examined. Addition of NaCl results in a slight increase in the partition coefficients of parabens in solutions of octylphenolpoly(ethyleneglycolether) and a more pronounced increase in the sodium dodecyl sulfate (SDS) system. The partition coefficients of ibuprofen increase on addition of NaCl to aqueous solutions of SDS and decrease if Bu(4)NBr is added to dodecyl trimethyl ammonium bromide (DTAB) solutions. Good agreement between experimental and calculated data shows a high potential of COSMO-RS in the prediction of micelle/water partition coefficients in the presence of electrolytes and makes it a valuable tool in drug and drug-carrier design as well as in optimizing micellar reactions or micelle-enhanced separation processes.
Authors with CRIS profile
Liudmila Mokrushina
Lehrstuhl für Thermische Verfahrenstechnik
Wolfgang Arlt
Lehrstuhl für Thermische Verfahrenstechnik
Involved external institutions
Germany (DE)How to cite
APA:
Wille, S., Mokrushina, L., Smirnova, I., & Arlt, W. (2010). Partition Coefficients of Alkyl Parabens and Ibuprofen in Micellar Systems. Chemical Engineering & Technology, 33(12), 2095-2101. https://dx.doi.org/10.1002/ceat.201000279
MLA:
Wille, Susanne, et al. "Partition Coefficients of Alkyl Parabens and Ibuprofen in Micellar Systems." Chemical Engineering & Technology 33.12 (2010): 2095-2101.
BibTeX: Download