The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine
Busch S, Unruh T (2011)
Publication Status: Published
Publication Type: Journal article
Publication year: 2011
Journal
Publisher: ELSEVIER SCIENCE BV
Book Volume: 1808
Pages Range: 199-208
Journal Issue: 1
DOI: 10.1016/j.bbamem.2010.10.012
Abstract
The influence of additives on the molecular dynamics of the phospholipid dimyristoylphosphatidylcholine (DMPC) in its fully hydrated liquid crystalline phase was studied. Quasielastic neutron scattering (QENS) was used to detect motions with dimensions of some Angstroms on two different time scales, namely 60 ps and 900 Ps. The effects of myristic acid, farnesol, cholesterol, and sodium glycocholate could consistently be explained on the basis of collective, flow-like motions of the phospholipid molecules. The influence of the additives on these motions was explained by packing effects, corresponding to the reduction of free volume. Cholesterol was found to decrease the mobility of DMPC seen on the 900 ps time scale with increasing cholesterol content. In contrast, all other studied additives have no significant effect on the mobility. (C) 2010 Elsevier B.V. All rights reserved.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Busch, S., & Unruh, T. (2011). The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. Biochimica Et Biophysica Acta-Biomembranes, 1808(1), 199-208. https://doi.org/10.1016/j.bbamem.2010.10.012
MLA:
Busch, Sebastian, and Tobias Unruh. "The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine." Biochimica Et Biophysica Acta-Biomembranes 1808.1 (2011): 199-208.
BibTeX: Download