Suzuki cross-coupling in aqueous media

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Hoffmann I, Blumenröder B, Onodi S, Dommer S, Schatz J
Zeitschrift: Green Chemistry
Verlag: Royal Society of Chemistry
Jahr der Veröffentlichung: 2015
Band: 17
Heftnummer: 7
Seitenbereich: 3844-3857
ISSN: 1463-9262
eISSN: 1463-9270


Abstract


We report a simple and efficient procedure for the ligand-free as well as ligand-assisted Suzuki reaction in both pure water and aqueous media. The cross-coupling reactions proceed successfully using phenylboronic acid or potassium phenyltrifluoroborate as a nucleophilic coupling partner. The method can be effectively applied to both activated and deactivated aryl halides yielding quantitative conversions. The catalytic activity of couplings performed in pure water increases when utilizing supramolecular additives, but decreases under standard phase-transfer conditions. Finally, the palladium loading is reducible from 3.0 mol% to 0.4 mol% without any loss of conversion.



FAU-Autoren / FAU-Herausgeber

Blumenröder, Bettina
Lehrstuhl für Organische Chemie I
Dommer, Sabine
Professur für Organische Chemie
Hoffmann, Ina
Professur für Organische Chemie
Onodi, Silvia
Professur für Organische Chemie
Schatz, Jürgen Prof. Dr.
Professur für Organische Chemie


Zitierweisen

APA:
Hoffmann, I., Blumenröder, B., Onodi, S., Dommer, S., & Schatz, J. (2015). Suzuki cross-coupling in aqueous media. Green Chemistry, 17(7), 3844-3857. https://dx.doi.org/10.1039/c5gc00794a

MLA:
Hoffmann, Ina, et al. "Suzuki cross-coupling in aqueous media." Green Chemistry 17.7 (2015): 3844-3857.

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Zuletzt aktualisiert 2019-06-04 um 14:50