Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability

Boccardi E, Philippart A, Juhasz-Bortuzzo J, Beltrán AM, Novajra G, Vitale-Brovarone C, Spiecker E, Boccaccini AR (2015)

Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Frontiers in Bioengineering and Biotechnology Frontiers Media

Book Volume: 3

Article Number: 177

DOI: 10.3389/fbioe.2015.00177

Abstract

The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability.

Authors with CRIS profile

Elena Boccardi Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Anahi Philippart Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Erdmann Spiecker Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Additional Organisation(s)

Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung) Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)

Involved external institutions

Politecnico di Torino IT Italy (IT)

How to cite

APA:

Boccardi, E., Philippart, A., Juhasz-Bortuzzo, J., Beltrán, A.M., Novajra, G., Vitale-Brovarone, C.,... Boccaccini, A.R. (2015). Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability. Frontiers in Bioengineering and Biotechnology, 3. https://doi.org/10.3389/fbioe.2015.00177

MLA:

Boccardi, Elena, et al. "Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability." Frontiers in Bioengineering and Biotechnology 3 (2015).

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